The Herbal Minefield

Stephen Barrett, M.D.

Americans spend billions of dollars per year for capsules, tablets, bulk herbs, and herbal teas. Although many of these items are consumed for their flavor, most are probably used for supposed medicinal qualities. Multilevel distributors and pharmacies offer many products that are obviously intended for self-medication. Herbs are also marketed by naturopaths, acupuncturists, iridologists, chiropractors, offbeat nutritionists, and unlicensed herbalists, many of whom prescribe them for the entire gamut of health problems. Most such practitioners are not qualified to make appropriate medical diagnoses or to determine how the products they prescribe compare to proven drugs.

Herbal advocates like to point out that about half of today's medicines were derived from plants. (Digitalis, for example, was originally derived from leaves of the foxglove plant.) This statement is true but misleading. Drug products contain specified amounts of active ingredients. Herbs in their natural state can vary greatly from batch to batch and often contain chemicals that cause side effects but provide no benefit.

When potent natural substances are discovered, drug companies try to isolate and synthesize the active chemical in order to provide a reliable supply. They also attempt to make derivatives that are more potent, more predictable, and have fewer side effects. In the case of digitalis, derivatives provide a spectrum of speed and duration of action. Digitalis leaf is almost never used today because its effects are less predictable. Many herbs contain hundreds or even thousands of chemicals that have not been completely cataloged. Some of these chemicals may turn out to be useful as therapeutic agents, but others could well prove toxic.

Even when a botanical product contains ingredients that are potentially effective, it may not be practical to use. Garlic, for example, has been demonstrated to lower cholesterol. However, prescription drugs are more potent for this purpose, and garlic has anticoagulant properties. No data are available to indicate the risk of combining garlic with other widely used products (vitamin E, ginkgo, fish oil, and aspirin) that can interfere with blood clotting.

Little Public Protection

In the United States, herbs intended for preventive or therapeutic use would be regulated as drugs under federal laws. To evade the law, these products are marketed as "foods" or "dietary supplements" without health claims on their labels. Since these are not regulated as drugs, no legal standards exist for their processing, harvesting, or packaging. In many cases, particularly for products with expensive raw ingredients, contents and potency are not accurately disclosed on the label. Many products marked as herbs contain no useful ingredients, and some even lack the principal ingredient for which people buy them. Surveys have found have found that the ingredients and doses of several products varied considerably from brand to brand.

Some manufacturers are trying to develop industrywide quality-assurance standards, but possible solutions are a long way off.

Regulation Is Minimal

The Dietary Supplement Health and Education Act of 1994 included herbal products in its definition of "dietary supplements," even though herbs have little or no nutritional value. (The bill was spearheaded by the health-food industry in order to weaken FDA regulation of its products.) Herbal or other botanical ingredients include processed or unprocessed plant parts (bark, leaves, flowers, fruits, and stems) as well as extracts and essential oils. They are available as teas, powders, tablets, capsules, and elixirs, and may be marketed as single substances or combined with other herbs, vitamins, minerals, amino acids, or non-nutrient ingredients. Products containing multiple herbal ingredients may produce adverse effects that are impossible to predict. A 1999 survey by Prevention magazine found that 12% of herbal remedy users reported adverse reactions [7].

The manufacture of prescription and over-the-counter drugs is closely regulated by the FDA, But herbal products are not [8]. Even the fact that an herb is known to be toxic does not ensure its removal from the marketplace. When the FDA concludes that an herb is dangerous, it usually issues a warning rather than a ban. Several years ago, the FDA Center for Food Safety and Applied Nutrition maintained a database of reports the FDA has received of adverse events associated with the use of dietary supplements and herbal products. However, the database is no longer posted because the FDA could not be certain that the reported problems were caused by the products or had occurred for other reasons.

Much Unreliable Information

To make a rational decision about an herbal product, it would be necessary to know what it contains, whether it is safe, and whether it has been demonstrated to be as good or better than pharmaceutical products available for the same purpose. For most herbal ingredients this information is incomplete or unavailable. Even worse, most published information about herbs is unreliable. The late Varro E. Tyler, Ph.D., former dean of the Purdue University School of Pharmacy and a leading authority on pharmacognosy (the science of medicines from natural sources), observed:

More misinformation about the safety and efficacy of herbs is reaching the public currently than at any previous time, including the turn-of-the-century heyday of patent medicines. The literature promoting herbs includes pamphlets, magazine articles, and books ranging in quality from cheaply printed flyers to elaborately produced studies in fine bindings with attractive illustrations. Practically all of these writings recommend large numbers of herbs for treatment based on hearsay, folklore, and tradition. The only criterion that seems to be avoided in these publications is scientific evidence. Some writings are so comprehensive and indiscriminate that they seem to recommend everything for anything. Even deadly poisonous herbs are sometimes touted as remedies, based on some outdated report or a misunderstanding of the facts. Particularly insidious is the myth that there is something almost magical about herbal drugs that prevents them, in their natural state, from harming people [9].

Two of Tyler's books (The Honest Herbal and Herbs of Choice) summarize what is known about many commonly used herbs, as do several published guidebooks for professionals. However, for most substances, not enough is known to make well-informed decisions about their use. The American Botanical Council, which markets many science-based herbal guidebooks, includes several unreliable books in its otherwise valuable catalog. In 1996, I asked the council's executive director Mark Blumenthal to purge the catalog of books that contain highly irresponsible or quack advice. When he refused, I made a similar request to Tyler, who was a member of the Council's 7-person board of trustees. But the books I complained about remained in the catalog, and several other quacky ones were added.

A study published in 2002 found that many sites located by searching for "herbs" and "cancer cure" contained illegal claims [10]. I advise consumers to ignore advice from anyone who has a financial interest in the sale of dietary supplements, herbs, or homeopathic products.

Researchers from Harvard have evaluated claims made on 443 Web sites located by searching for information about eight widely used herbal supplements (ginkgo biloba, St. John's wort, echinacea, ginseng, garlic, saw palmetto, kava kava, and valerian root) [11]. The researchers concluded:

The involvement of drug companies into the herbal marketplace may improve standardization of dosage for a few products. And public and professional interest in herbs is likely to stimulate more research. However, with safe and effective medicines available, treatment with herbs rarely makes sense, and many of the conditions for which herbs are recommended are not suitable for self-treatment.

Reliable Information Sources

Reviews of Books to Avoid

References

  1. Good Housekeeping Institute. New Good Housekeeping Institute study finds drastic discrepancy in potencies of popular herbal supplement. News release, Consumer Safety Symposium on Dietary Supplements and Herbs, New York City, March 3, 1998.
  2. Monmaney T. Labels' potency claims often inaccurate, analysis finds. Spot check of products finds widely varying levels of key ingredient. But some firms object to testing method and defend their brands' quality. Los Angeles Times, Aug 31, 1998.
  3. Gurley BJ and others. Content versus label claims in ephedra-containing dietary supplements. American Journal of Health-System Pharmacists 57:963-969, 2000. [PDF]
  4. Roffman GE. Herbal remedy ripoffs. D Magazine, April 2000.
  5. Garrard S and others. Variations in product choices of frequently purchased herbs: Caveat emptor. Archives of Internal Medicine 163:2290-2295, 2003.
  6. Newmaster SG and others. DNA barcoding detects contamination and substitution in North American herbal products. BMC Medicine 11:222, 2013.
  7. Survey of Consumer Use of Dietary Supplements. Emmaus, PA: Rodale Press, 1999.
  8. Hasegawa GR. Uncertain quality of dietary supplements: History repeated. American Journal of Health-System Pharmacists 57:951 2000.
  9. Tyler VE. The overselling of herbs. In Barrett S, Jarvis T, editors: The Health Robbers: A Close Look at Quackery in America. Amherst, NY: Prometheus Books, 1993.
  10. Bonakdar RA. Herbal cancer cures on the Web: Noncompliance with the Dietary Supplement Health and Education Act. Family Medicine 34:522-527, 2002.
  11. Morris CA, Avorn J. Internet marketing of herbal products. JAMA 290:1505-1509, 2003.
  12. Jellin JM, Batz F, Hitchens K, editors. Natural Medicines Comprehensive Database. Stockton, CA: Therapeutic Research Faculty, 1999.
  13. Marty AT. Natural Medicines Comprehensive Database (book review). JAMA 283:2992-2993, 2000.
  14. Hall HA. Diet supplements or nutritional supplements: A ruse by any other name is still a ruse. Science-Based Medicine Blog, Feb 2, 2011.

Reader Response (2/14/00)

You, sir, are the quack. How could you even think of saying, "With safe and effective medicines available, treatment with herbs rarely makes sense."? The correct statement would be: "With all those dangerous drugs available, with all those terrible side effects, treatment with herbs is the only choice." All pharmaceuticals are toxic to the human body. Over 150,000 hospital patients die every year from taking the prescribed dosage of a drug prescribed to them by their doctor. Drugs have their place—in emergencies only—or when a condition has become so bad that the patient is willing to deal with the side effects in order to treat the main problem. Modern "medicine" is more of a scam than herbal medicine could ever be. If people with health problems would stay away from drug stores and spend more time in health food stores, people would live longer, stay healthier, and have a better quality of life. Talk to the men who take blood pressure "medicine" and can no longer get an erection. Talk to the relatives of the men who died from taking viagra. Drugs only address the symptoms, herbs address the cause. Drugs simply mask the symptoms, herbs assist in the healing.

I have a B.S. in education from Indiana State University, have been studying natural medicine for 17 years, and have been working as a health food store manager and nutritional consultant for 7 years. My disdain for pharmaceutical industry is the result of hearing the horror stories of my customers about the side effects of the drugs they have used. Many of the herb shop customers of today are people who have had bad experiences with prescription drugs and/or doctors who won't listen to or work with them. In a way i am thankful for the drug industry, because they drive many people into health food stores. I don't mean to imply that there is no place for drugs, because there definitely is a place for them. However drugs should be the last resort.

This article was revised on November 23, 2013.

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